Diagnostic role of tests for T cell receptor (TCR) genes

Diagnostic role of tests for T cell receptor (TCR) genes.

Rapid advances in molecular biological techniques have made it possible to study disease pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease. Using techniques such as Southern blot hybridi...

T cell receptor (TCR) locus enhancer identity and position are critical for the assembly of TCR and variable region genes

T cell receptor (TCR) and variable region genes are assembled from germ-line gene segments located in a single chromosomal locus in which TCR segments are situated between TCR segments. The TCR enhancer (E ) located at the 3 end of the TCR locus functions over a long chromosomal distance to promote TCR rearrangement and maximal TCR expression; whereas the TCR enhancer (E ) is located among the ...

Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System

The CDR3 regions of T cell receptor (TCR)-alpha and -beta chains play central roles in the recognition of antigen (Ag)-MHC complex. TCR repertoire is created on the basis of Ag recognition specificity by CDR3s. To analyze the potential spectrum of TCR-alpha and -beta to exhibit Ag specificity and generate TCR repertoire, we established hundreds of TCR transfectants bearing a single TCR-alpha or...

Prerearranged T Cell Receptor Genes Development in Mice with Endogenous Early TCR Expression and Aberrant T Cell

Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire

Immature thymocytes undergo a selection process within the thymus based on their T cell antigen receptor (TCR) specificity that results either in their maturation into functionally competent, self-MHC-restricted T cells (positive selection) or their deletion (negative selection). The outcome of thymocyte selection is thought to be controlled by signals transduced by the TCR that vary in relatio...